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- Title
Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures.
- Authors
Demarchi, Luiz Henrique Ferraz; Bandeira, Larissa Melo; Taira, Deborah Ledesma; Zardin, Marina Castilhos Souza Umaki; Ibanhes, Mary Luizia; Esposito, Ana Olivia Pascoto; de Arruda, Larissa Domingues Castilho; Gonçalves, Crhistinne Cavalheiro Maymone; Weis-Torres, Sabrina Moreira dos Santos; Cesar, Gabriela Alves; da Cunha, Rivaldo Venâncio; Tanaka, Tayana Serpa Ortiz; Puga, Marco Antonio Moreira; de Rezende, Grazielli Rocha; Lopes, Roberta Barbosa; Uehara, Silvia Naomi de Oliveira; Pinho, João Renato Rebello; Carrilho, Flair Jose; Gomes-Gouvêa, Michele Soares; Motta-Castro, Ana Rita Coimbra
- Abstract
This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (n = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9–14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4–69.4%). In contrast, only 19.2% (CI 95%: 17.6–20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (n = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.
- Subjects
SAO Paulo (Brazil); HEPATITIS B vaccines; DISEASE risk factors; VIRUS diseases; HEPATITIS B
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 5, p1085
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14051085