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- Title
A Metallo Pro‐Drug to Target Cu<sup>II</sup> in the Context of Alzheimer's Disease.
- Authors
Conte‐Daban, Amandine; Ambike, Vinita; Guillot, Régis; Delsuc, Nicolas; Policar, Clotilde; Hureau, Christelle
- Abstract
Abstract: Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a MnII‐based superoxide dismutase (SOD) mimic ([MnII(L)]+, <bold>1+</bold>) as a pro‐drug candidate to target CuII‐associated events, namely, CuII‐induced formation of reactive oxygen species (ROS) and modulation of the amyloid‐β (Aβ) peptide aggregation. Complex <bold>1+</bold> is able to remove CuII from Aβ, stop ROS and prevent alteration of Aβ aggregation as would do the corresponding free ligand LH. Using <bold>1+</bold> instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD‐like activity.
- Subjects
OXIDATIVE stress; ALZHEIMER'S disease; SUPEROXIDE dismutase; MANGANESE enzymes; REACTIVE oxygen species
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 20, p5095
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201706049