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- Title
An Oxidant-Free and Mild Strategy for Quinazolin-4(3 H)-One Synthesis via CuAAC/Ring Cleavage Reaction.
- Authors
He, Yueling; Yang, Zhongtao; Luo, Danyang; Luo, Xiai; Chen, Xiaodong; Yang, Weiguang
- Abstract
An oxidant-free and highly efficient synthesis of phenolic quinazolin-4(3H)-ones was achieved by simply stirring a mixture of 2-aminobenzamides, sulfonyl azides, and terminal alkynes. The intermediate N-sulfonylketenimine underwent two nucleophilic additions and the sulfonyl group eliminated through the power of aromatization. The natural product 2-(4-hydroxybenzyl)quinazolin-4(3H)-one can be synthesized on a large scale under mild conditions with this method.
- Subjects
SULFONYL group; SULFONYL azides; NATURAL products; AROMATIZATION; SULFONYL chlorides; ALKYNES
- Publication
Molecules, 2023, Vol 28, Issue 15, p5734
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28155734