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- Title
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis.
- Authors
He, Ze-Hui; Zou, Jing-Tao; Chen, Xia; Gong, Jiang-Shan; Chen, Ya; Jin, Ling; Liu, Yi-Wei; Rao, Shan-Shan; Yin, Hao; Tan, Yi-Juan; Wang, Zun; Du, Wei; Li, Hong-Ming; Qian, Yu-Xuan; Wang, Zhen-Xing; Wang, Yi-Yi; Wan, Teng-Fei; Luo, Yi; Zhu, Hao; Chen, Chun-Yuan
- Abstract
Objective: Nanoparticles (NPs) hold a great promise in combating rheumatoid arthritis, but are often compromised by their toxicities because the currently used NPs are usually synthesized by chemical methods. Our group has previously fabricated Ångstrom-scale silver particles (AgÅPs) and demonstrated the anti-tumor and anti-sepsis efficacy of fructose-coated AgÅPs (F-AgÅPs). This study aimed to uncover the efficacy and mechanisms of F-AgÅPs for arthritis therapy. Methods: We evaluated the efficacy of F-AgÅPs in collagen-induced arthritis (CIA) mice. We also compared the capacities of F-AgÅPs, the commercial AgNPs, and the clinical drug methotrexate (MTX) in protecting against K/BxN serum-transfer arthritis (STA) mice. Moreover, we evaluated the effects of F-AgÅPs and AgNPs on inflammation, osteoclast formation, synoviocytes migration, and matrix metalloproteinases (MMPs) production in vitro and in vivo. Meanwhile, the toxicities of F-AgÅPs and AgNPs in vitro and in vivo were also tested. Results: F-AgÅPs significantly prevented bone erosion, synovitis, and cartilage damage, attenuated rheumatic pain, and improved the impaired motor function in mouse models of CIA or STA, the anti-rheumatic effects of which were comparable or stronger than AgNPs and MTX. Further studies revealed that F-AgÅPs exhibited similar or greater inhibitory abilities than AgNPs to suppress inflammation, osteoclast formation, synoviocytes migration, and MMPs production. No obvious toxicities were observed in vitro and in vivo after F-AgÅPs treatment. Conclusions: F-AgÅPs can effectively alleviate arthritis without notable toxicities and their anti-arthritic effects are associated with the inhibition of inflammation, osteoclastogenesis, synoviocytes migration, and MMPs production. Our study suggests the prospect of F-AgÅPs as an efficient and low-toxicity agent for arthritis therapy.
- Subjects
COLLAGEN-induced arthritis; OSTEOCLASTOGENESIS; RHEUMATOID arthritis; INFLAMMATION; ANTIARTHRITIC agents; MATRIX metalloproteinases
- Publication
Inflammation Research, 2023, Vol 72, Issue 10/11, p2053
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-023-01778-0