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- Title
Accelerated Aging and the Life Course of Individuals Born Preterm.
- Authors
Bousquet, Audrey; Sanderson, Keia; O'Shea, T. Michael; Fry, Rebecca C.
- Abstract
Individuals born preterm have shorter lifespans and elevated rates of chronic illness that contribute to mortality risk when compared to individuals born at term. Emerging evidence suggests that individuals born preterm or of low birthweight also exhibit physiologic and cellular biomarkers of accelerated aging. It is unclear whether, and to what extent, accelerated aging contributes to a higher risk of chronic illness and mortality among individuals born preterm. Here, we review accelerated aging phenotypes in adults born preterm and biological pathways that appear to contribute to accelerated aging. We highlight biomarkers of accelerated aging and various resiliency factors, including both pharmacologic and non-pharmacologic factors, that might buffer the propensity for accelerated aging among individuals born preterm.
- Subjects
EVALUATION of medical care; BIOMARKERS; COGNITION disorders; PREMATURE infants; LUNG diseases; HUMAN life cycle; CARDIOVASCULAR diseases; SARCOPENIA; RISK assessment; KIDNEY diseases; AGING; DEMENTIA; PHENOTYPES; PSYCHOLOGICAL resilience; ADULTS
- Publication
Children, 2023, Vol 10, Issue 10, p1683
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children10101683