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- Title
SARS-CoV-2 Serostatus and COVID-19 Illness Characteristics by Variant Time Period in Non-Hospitalized Children and Adolescents.
- Authors
Messiah, Sarah E.; Swartz, Michael D.; Abbas, Rhiana A.; Talebi, Yashar; Kohl III, Harold W.; Valerio-Shewmaker, Melissa; DeSantis, Stacia M.; Yaseen, Ashraf; Kelder, Steven H.; Ross, Jessica A.; Padilla, Lindsay N.; Gonzalez, Michael O.; Wu, Leqing; Lakey, David; Shuford, Jennifer A.; Pont, Stephen J.; Boerwinkle, Eric
- Abstract
Objective: To describe COVID-19 illness characteristics, risk factors, and SARS-CoV-2 serostatus by variant time period in a large community-based pediatric sample. Design: Data were collected prospectively over four timepoints between October 2020 and November 2022 from a population-based cohort ages 5 to 19 years old. Setting: State of Texas, USA. Participants: Participants ages 5 to 19 years were recruited from large pediatric healthcare systems, Federally Qualified Healthcare Centers, urban and rural clinical practices, health insurance providers, and a social media campaign. Exposure: SARS-CoV-2 infection. Main Outcome(s) and Measure(s): SARS-CoV-2 antibody status was assessed by the Roche Elecsys® Anti-SARS-CoV-2 Immunoassay for detection of antibodies to the SARS-CoV-2 nucleocapsid protein (Roche N-test). Self-reported antigen or PCR COVID-19 test results and symptom status were also collected. Results: Over half (57.2%) of the sample (N = 3911) was antibody positive. Symptomatic infection increased over time from 47.09% during the pre-Delta variant time period, to 76.95% during Delta, to 84.73% during Omicron, and to 94.79% during the Omicron BA.2. Those who were not vaccinated were more likely (OR 1.71, 95% CI 1.47, 2.00) to be infected versus those fully vaccinated. Conclusions: Results show an increase in symptomatic COVID-19 infection among non-hospitalized children with each progressive variant over the past two years. Findings here support the public health guidance that eligible children should remain up to date with COVID-19 vaccinations.
- Subjects
COVID-19; SARS-CoV-2; VIRAL proteins; CONFIDENCE intervals; TIME; COVID-19 vaccines; RISK assessment; DESCRIPTIVE statistics; RESEARCH funding; QUESTIONNAIRES; LOGISTIC regression analysis; ODDS ratio; HOSPITAL care of children
- Publication
Children, 2023, Vol 10, Issue 5, p818
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children10050818