We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.
- Authors
Wan, Yisong Y.; Hongbo Chi; Min Xie; Schneider, Michael D.; Flavell, Richard A.
- Abstract
The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however. We show here that T cell–specific deletion of the gene encoding TAK1 resulted in reduced development of thymocytes, especially of regulatory T cells expressing the transcription factor Foxp3. In mature thymocytes, TAK1 was required for interleukin 7–mediated survival and T cell receptor–dependent activation of transcription factor NF-κB and the kinase Jnk. In effector T cells, TAK1 was dispensable for T cell receptor–dependent NF-κB activation and cytokine production, but was important for proliferation and activation of the kinase p38 in response to interleukins 2, 7 and 15. Thus, TAK1 is essential for the integration of T cell receptor and cytokine signals to regulate the development, survival and function of T cells.
- Subjects
B cells; T cell receptors; INTERLEUKINS; CYTOKINES; LYMPHOCYTES; IMMUNOLOGY
- Publication
Nature Immunology, 2006, Vol 7, Issue 8, p851
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1355