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- Title
The effect of an antioxidant complex and exercise on induced lymphedema in rats.
- Authors
Puşcaş, Dina; Tache, Simona; Moldovan, Remus
- Abstract
Background. The incidence and complexity of breast cancer related lymphedema determined us to study the effect of an antioxidant complex and of physical activity on lymphedema in female rats. Aims. Redox homeostasis in animals with induced lymphedema, the effect of physical exercise and of supplementation with an antioxidant complex with phyto-homeopathic properties were studied. Methods. The research was conducted on female Wistar rats, assigned to 5 groups (n = 10 animals/group): group I - control group; groups 11-IV were operated for right axillary lymph node excision; group III was subjected to physical exercise; group IV was supplemented with an antioxidant complex; group V was subjected to physical exercise and supplemented with an antioxidant complex. Forelimb volume was measured to assess lymphedema before surgery and on days 3, 7, 14, 21 postsurgery. Redox homeostasis was determined based on the values of malonaldehyde (MDA) and thiol groups (SH) on day 21 post-surgery. Results. At 21 days, we found a reduction in the volume of the affected limb after the regular exercise program and supplementation with the antioxidant complex. Conclusions. Supplementation with the antioxidant complex has a positive role in improving lymphedema.
- Subjects
LYMPHEDEMA treatment; THERAPEUTIC use of antioxidants; EXERCISE physiology
- Publication
Palestrica of the Third Millennium Civilization & Sport, 2016, Vol 17, Issue 3, p193
- ISSN
1582-1943
- Publication type
Article