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- Title
Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia.
- Authors
Weng, Te-Fu; Ho, Mao-Wang; Lin, Hsiao-Chuan; Lu, Meng-Yao; Peng, Ching-Tien; Wu, Kang-Hsi
- Abstract
Weng T-F, Ho M-W, Lin H-C, Lu M-Y, Peng C-T, Wu K-H. Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia. Pediatr Transplantation 2012: 16: E35-E38. © 2010 John Wiley & Sons A/S. Abstract: Concomitant infections are frequent and usually the causes of death in patients with severe AA. HSCT can restore hematopoiesis in AA, but it is usually life threatening when patients simultaneously have an IFI. Mixed IFIs have been reported on rare occasions. The exact diagnosis of IFIs is difficult because of low fungus culture rate, difficultly obtaining tissue specimens in severely immunocompromised patients or those with bleeding tendencies. Otherwise, treatment with anti-fungal drugs alone for DMIFI was always lethal in previous reports. Surgical resection is crucial for invasive zygomycosis, but severe pancytopenia and bleeding tendency make therapy difficult. Herein, we report that with a combination of aggressive anti-fungal drugs, HSCT, and surgery, we successfully treated a 10-yr-old boy with severe AA and pulmonary zygomycosis before HSCT and disseminated mixed invasive zygomycosis and aspergillosis after HSCT.
- Subjects
CASE studies; COMMUNICABLE disease treatment; MYCOSES; INTRODUCED fungi; ANTIFUNGAL agents; HEMATOPOIETIC stem cell transplantation; APLASTIC anemia; FUNGAL cultures; SURGICAL excision
- Publication
Pediatric Transplantation, 2012, Vol 16, Issue 2, pE35
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/j.1399-3046.2010.01406.x