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- Title
Association of low skeletal muscle mass with the presence of advanced colorectal neoplasm: integrative analysis using three skeletal muscle mass indices.
- Authors
Lee, H. J.; Lee, J. Y.; Lee, M. J.; Kim, H.‐K.; Kim, N.; Kim, G.‐U.; Lee, J.‐S.; Park, H. W.; Chang, H.‐S.; Yang, D.‐H.; Choe, J.; Byeon, J.‐S.
- Abstract
Aim: This study aimed to evaluate an association between colorectal neoplasm (CRN) and skeletal muscle mass using three widely accepted skeletal muscle mass indices (SMIs) in a large population at average risk. Method: We performed a cross‐sectional study using a screening colonoscopy database of 33 958 asymptomatic subjects aged 40–75 years. Appendicular skeletal muscle mass (ASM) was measured using a bioelectrical impedance analyser. ASM adjusted for height squared (ASM/ht2), weight (ASM/wt) and body mass index (ASM/BMI) were used as indices for muscle mass. Logistic regression models were used to evaluate the association between SMIs and CRN. Results: In a multivariable‐adjusted model, the risk of an advanced CRN increased linearly with decreasing quartiles for all three SMIs. The adjusted odds ratios (ORs) for advanced CRN in quartiles 1, 2 and 3 of ASM/wt compared with that in quartile 4 were 1.279, 1.196 and 1.179, respectively (Ptrend = 0.017); for ASM/BMI, ORs were 1.307, 1.144 and 1.091, respectively (Ptrend = 0.002); and for ASM/ht2, ORs were 1.342, 1.169 and 1.062, respectively (Ptrend = 0.002). The risk of distally located advanced CRN was higher in quartile 1 than in quartile 4 for all three SMIs (ASM/wt, OR = 1.356; ASM/BMI, OR = 1.383; ASM/ht2, OR = 1.430). Conclusion: Our study demonstrated that low skeletal muscle mass was consistently associated with the presence of advanced CRN in a population at average risk regardless of the operational definition of the SMI, and it was particularly associated with distal advanced CRN.
- Subjects
MUSCLE mass; SKELETAL muscle; BODY mass index; BIOELECTRIC impedance; TUMORS
- Publication
Colorectal Disease, 2020, Vol 22, Issue 10, p1293
- ISSN
1462-8910
- Publication type
Article
- DOI
10.1111/codi.15103