We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polymorphisms of the HTR3B gene are associated with post-surgery emesis in a Chinese Han population.
- Authors
Ma, Xiao‐Xu; Chen, Qi‐Xing; Wu, Shui‐Jing; Hu, Yan; Fang, Xiang‐Ming
- Abstract
What is known and Objectives The serotoninergic receptor 5-hydroxytryptamine (serotonin) receptor 3 ( HTR3) is instrumental in the regulation of nausea and emesis (vomiting).This study investigated whether common genomic variations of the A and B subunits of HTR3 ( HTR3A, HTR3B) are associated with the incidence of post-operative vomiting in a Chinese Han population. Methods Two hundred and thirty-one female Chinese Han patients undergoing gynaecological surgery with standardized general anaesthesia were recruited for the study. Clinical symptoms after surgery were recorded and direct DNA sequencing was performed to detect polymorphisms of HTR3A and HTR3B. Results Five single nucleotide polymorphisms ( SNPs) in HTR3A and HTR3B were found, with R2 > 0·8 and minor allele frequency > 10%. One of these (rs3758987 in HTR3B) was statistically associated with vomiting, after adjusting for body weight, body mass index and duration of general anaesthesia in dominant and additive models ( P = 0·047 and P = 0·034). What is new and Conclusion The HTR3B rs3758987 SNP might serve as a predictor of post-operative vomiting in Chinese Han patients undergoing gynaecological laparoscopic surgery.
- Subjects
CHI-squared test; CHINESE people; CONFIDENCE intervals; POLYMERASE chain reaction; RESEARCH funding; SURVIVAL analysis (Biometry); T-test (Statistics); VOMITING; PROPORTIONAL hazards models; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; GENERAL anesthesia; SEQUENCE analysis; SYMPTOMS
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2013, Vol 38, Issue 2, p150
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/jcpt.12033