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- Title
Plasma Lp-PLA<sub>2</sub> mass and apoB-lipoproteins that carry Lp-PLA<sub>2</sub> decrease after sodium.
- Authors
Constantinides, Alexander; Kerstens, Michiel N.; Dikkeschei, Bert D.; van Pelt, L. Joost; Tellis, Constantinos C.; Tselepis, Alexandros D.; Dullaart, Robin P. F.
- Abstract
Eur J Clin Invest 2012; 42 (11): 1235-1243 Abstract Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel cardiovascular risk marker, which is predominantly complexed to apolipoprotein (apo) B-containing lipoproteins in human plasma. As increasing dietary sodium intake may decrease plasma apoB-containing lipoproteins, we tested whether a sodium challenge lowers plasma Lp-PLA2 mass, as well as the levels of apoB-containing lipoprotein particles carrying Lp-PLA2 (apoB-Lp-PLA2), employing a newly developed enzyme-linked immunosorbent assay. Materials and methods In 45 women and 31 men (mean age 44 ± 14 years), plasma Lp-PLA2 mass (turbidimetric immunoassay), the level of apoB-Lp-PLA2, expressed in apoB concentration and lipoproteins were measured in response to a 3-day challenge with 9 g sodium chloride tablets daily. Results Urinary sodium excretion increased from 165 ± 60 to 321 ± 70 mmol/24 h ( P < 0·001) after salt loading. Plasma Lp-PLA2 mass decreased from 618 (493-719) to 588 (465-698) μg/L ( P < 0·001), and apoB-Lp-PLA2 decreased from 0·276 (0·200-0·351) to 0·256 (0·189-0·328) g LDL protein/L ( P = 0·004) in response to the sodium challenge together with decreases in plasma total cholesterol, nonhigh-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein B and the total cholesterol/HDL cholesterol ratio ( P < 0·01 for all). Changes in plasma Lp-PLA2 mass were correlated positively with changes in total cholesterol, LDL cholesterol and non-HDL cholesterol ( r = 0·260-0·276, P < 0·05 to P < 0·02), whereas changes in apoB-Lp-PLA2 were correlated positively with changes in non-HDL cholesterol and in the total cholesterol/HDL cholesterol ratio ( r = 0·232-0·385, P < 0·05-0·01). Conclusion Both plasma Lp-PLA2 mass levels and apoB-Lp-PLA2 decrease in response to a short-term oral sodium challenge.
- Subjects
LIPOPROTEINS; PHOSPHOLIPASE A2; ANGIOTENSINS; ALDOSTERONE synthesis; ENZYME-linked immunosorbent assay
- Publication
European Journal of Clinical Investigation, 2012, Vol 42, Issue 11, p1235
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/j.1365-2362.2012.02719.x