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- Title
Serum nesfatin‐1 is associated with testosterone and the severity of erectile dysfunction.
- Authors
Sun, Wei; Bi, Liang‐Kuan; Xie, Dong‐Dong; Yu, De‐Xin
- Abstract
This cross‐sectional study aimed to evaluate serum nesfatin‐1 concentrations in patients with erectile dysfunction (ED). Patients with ED were selected from the Department of Urology of the Second Affiliated Hospital of Anhui Medical University. The International Index of Erectile Function‐5 (IIEF‐5) was used to evaluate the severity of ED. Serum nesfatin‐1 and gonadal hormone levels, including luteinising hormone (LH), follicle‐stimulating hormone (FSH) and testosterone were measured. The IIEF‐5 scores (t = −21.034, p <.001) and nesfatin‐1 levels (t = −7.043, p <.001) in patients with ED were significantly lower than in healthy controls. Moreover, patients with ED showed decreased testosterone levels (t = −3.478, p =.001), whereas there were no significant differences in serum levels of FSH (t = −0.088, p =.930) and LH (t = 1.114, p =.270) between the two groups. Furthermore, positive relationships were found between serum nesfatin‐1 and testosterone concentrations (r =.742, p =.001) and IIEF‐5 scores (r =.395, p =.009) in ED patients. Additionally, based on receiver operating characteristic curve analysis, the area under curve for nesfatin‐1 was 0.884 with 83.3% sensitivity and 81.4% specificity in discriminating ED patients from healthy controls. The decrease in serum nesfatin‐1 level may be related to testosterone and the severity of ED.
- Subjects
IMPOTENCE; RECEIVER operating characteristic curves; TESTOSTERONE; LUTEINIZING hormone; FOLLICLE-stimulating hormone
- Publication
Andrologia, 2020, Vol 52, Issue 7, p1
- ISSN
0303-4569
- Publication type
Article
- DOI
10.1111/and.13634