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- Title
Multimodality Image Post-processing in Detection of Extratemporal MRI-Negative Cortical Dysplasia.
- Authors
Hu, Wen-han; Wang, Xiu; Liu, Li-na; Shao, Xiao-qiu; Zhang, Kai; Ma, Yan-shan; Ai, Lin; Li, Jun-ju; Zhang, Jian-guo
- Abstract
<bold>Purpose:</bold> To determine the diagnostic value of individual image post-processing techniques in a series of patients who underwent extratemporal operations for histologically proven, MRI-negative focal cortical dysplasia (FCD). <bold>Methods:</bold> The morphometric analysis program (MAP), PET/MRI co-registration and statistical parametric mapping (SPM) analysis of PET (SPM-PET) techniques were analyzed in 33 consecutive patients. The epileptogenic zone (EZ) assumed by MAP, PET/MRI, and SPM-PET was compared with the location of the FCD lesions determined by stereoelectroencephalography (SEEG) and histopathological study. The detection rate of each modality was statistically compared. <bold>Results:</bold> Three lesions were simultaneously detected by the three post-processing methods, while two lesions were only MAP positive, and 8 were only PET/MRI positive. The detection rate of MAP, PET/MRI, SPM-PET and the combination of the three modalities was 24.2, 90.9, 57.6, and 97.0%, respectively. Taking the pathological subtype into account, no type I lesions were detected by MAP, and PET/MRI was the most sensitive method for detecting FCD types II and IIA. During a mean follow-up period of 22.94 months, seizure freedom was attained in 26/33 patients (78.8%) after focal corticectomy. <bold>Conclusions:</bold> MAP, PET/MRI, and SPM-PET provide complementary information for FCD detection, intracranial electrode design, and lesion resection. PET/MRI was particularly useful, with the highest detection rate of extratemporal MRI-negative FCD.
- Subjects
DYSPLASIA; NEURAL circuitry; MAGNETIC resonance imaging of the brain; DIAGNOSIS
- Publication
Frontiers in Neurology, 2018, pN.PAG
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2018.00450