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- Title
Gradual dose taper following chronic buprenorphine.
- Authors
Becker, Ami B.; Strain, Eric C.; Bigelow, George E.; Stitzer, Maxine L.; Johnson, Rolley E.; Becker, A B; Strain, E C; Bigelow, G E; Stitzer, M L; Johnson, R E
- Abstract
This paper describes the time course of withdrawal and relapse in opioid-dependent volunteers (n = 8) who completed a gradual outpatient buprenorphine dose taper (28 days). Compliance with treatment was very high, as evidenced by clinic attendance (96-100%). Urinalysis showed that 6 of the 8 volunteers had relapsed to opiates by the end of the dose taper, even though reports of withdrawal were generally low. Relapse may have been triggered by a desire to re-experience the drug's positive subjective effects, craving, or low motivation to remain drug-free. A longer taper combined with an expanded range of treatments may improve prognosis.
- Subjects
BUPRENORPHINE; MORPHINE derivatives; ANALGESICS; URINALYSIS; VOLUNTEERS; VOLUNTEER service
- Publication
American Journal on Addictions, 2001, Vol 10, Issue 2, p111
- ISSN
1055-0496
- Publication type
journal article
- DOI
10.1080/105504901750227778