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- Title
Primary and Metastatic Malignant Melanomas of the Digestive System.
- Authors
Kulahci, Ozgur; Turan, Gulay
- Abstract
Aim: Primary and metastatic digestive system malignant melanomas are extremely rare. In our study, we aimed to compare lymph node metastasis with clinical and pathological parameters in gallbladder, stomach, small intestine and anorectal region malignant melanom as. Patients and Methods: In our study, we evaluated the relationship between regional lymph node metastasis and age, gender, tumor localization, tumor size, extraintestinal melanoma history, melanin pigment, neutrophil-lymphocyte ratio and post-diagnosis life span in primary and metastatic malignant melanoma cases in the gastrointestinal system between 2010 and 2020. Results: There was a statistical relationship between tumor diameter and regional lymph node metastasis (p =0.000). As the tumor diameter increased, the lymph node metastasis rate increased. There was a relationship between survival and gender, tumor localization, distant metastasis, primary and metastatic digestive system melanoma (all p <0.05). Most of the men and those who did not metastasize away from the digestive system were alive. All patients with melanoma metastases to the digestive system and all patients with gallbladder and small intestine localization were alive. Our 70 year old patient with gallbladder primary malignant melanoma was the oldest patient we could identify in the literature. Conclusions: Regardless of cutaneous or origin, all melanomas originate from melanocytes, cells derived from embryological nerve crest. Malignant melanoma can be primary in every region, more frequently in the anorectal region in the gastrointestinal tract. Recently, in metastatic melanoma, immuno-oncological agents are used in adjuvant therapy to help prevent metastatic spread of the disease. Thanks to these treatments, it is reported that more than half of patients with melanoma who have the risk of metastasis after surgical resection provide recurrence-free survival. Although it is very rare, it should be kept in mind that there may be primary or metastatic malignant melanoma in the evaluation of digestive system biopsies.
- Subjects
DIGESTIVE organs; MELANOMA; LYMPHATIC metastasis; GASTROINTESTINAL system; METASTASIS; GALLBLADDER cancer; INTESTINAL tumors
- Publication
Selcuk University Medical Journal, 2020, Vol 36, Issue 4, p300
- ISSN
1017-6616
- Publication type
Article
- DOI
10.30733/std.2020.01463