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- Title
Stereotactic Irradiation of GH-Secreting Pituitary Adenomas.
- Authors
Minniti, G.; Scaringi, C.; Amelio, D.; Enrici, R. Maurizi
- Abstract
Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10-15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains amatter of debate. Stereotactic techniques have been developed with the aim to delivermore localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques.
- Subjects
ACROMEGALY; ADENOMA; PITUITARY tumors; STEREOTACTIC radiotherapy; SOMATOTROPIN; TUMOR growth
- Publication
International Journal of Endocrinology, 2012, p1
- ISSN
1687-8337
- Publication type
Article
- DOI
10.1155/2012/482861