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- Title
Patients with nephrotic-range proteinuria have apolipoprotein C and E deficient VLDL<sub>1</sub>.
- Authors
Deighan, Christopher J.; Caslake, Muriel J.; Mcconnell, Michael; Boulton-Jones, J. Michael; Packard, Christopher J.
- Abstract
Patients with nephrotic-range proteinuria have apolipoprotein C and E deficient VLDL1. Background. Impaired very low-density lipoprotein (VLDL) clearance contributes to dyslipidemia in nephrotic-range proteinuria. VLDL can be subdivided into large light VLDL1 (Sf 60 to 400) and smaller, denser VLDL2 (Sf 20 to 60). In nephrotic-range proteinuria, the clearance of VLDL1 is delayed. VLDL1 lipolysis is influenced by apolipoprotein CII (apoCII) and apoCIII, whereas apoE regulates receptor-mediated clearance. Methods. To ascertain whether impaired VLDL1 clearance was related to a deficiency in apolipoproteins on VLDL1, we measured VLDL subfraction concentrations and VLDL1 apolipoprotein and lipid compositions in 27 patients with glomerular disease and urinary albumin> 2 g/24 h along with 27 age- and sex-matched controls. Results. Proteinuric patients had increased plasma VLDL1, VLDL2, apoCII, apoCIII (all P < 0.001), and apoE concentration (P < 0.002). Patients appeared to have smaller VLDL1 particles, as assessed by triglyceride per particle (median + interquartile range, moles per VLDL1 particle): patients, 4.9 (3.0 to 7.9) ×103; controls, 7.0 (4.6 to 15.7) ×103, P < 0.05, with reduced apoCII, 4.2 (3.1 to 8.2) versus 9.9 (7.4 to 23.2), P < 0.0004; apoCIII, 16.6 (9.1 to 27.2) versus 29.3 (18.5 to 69.4), P < 0.02; and apoE content, 0.17 (0.08 to 0.44) versus 0.48 (0.31 to 1.31), P < 0.006. The VLDL1 surface free cholesterol to phospholipid results were increased in proteinuric patients (0.55 ± 0.17 vs. 0.40 ± 0.18, P < 0.002, all mean ± SD). For all patients, VLDL1 apoCII, apoCIII, and apoE contents per particle were related to particle size (apoCII, r2 = 61.5%, P < 0.001; apoCIII, r2 = 75.8%, P < 0.001; apoE, r2 =...
- Subjects
LOW density lipoproteins; PROTEINURIA; LIPOLYSIS; PATIENTS
- Publication
Kidney International, 2000, Vol 58, Issue 3, p1238
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.2000.00278.x