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- Title
Predictors of clinical‐pathologic stage discrepancy in oral cavity squamous cell carcinoma: A National Cancer Database study.
- Authors
Kılıç, Sarah S.; Kılıç, Suat; Crippen, Meghan M.; Varughese, Denny; Eloy, Jean Anderson; Baredes, Soly; Mahmoud, Omar M.; Park, Richard Chan Woo
- Abstract
Abstract: Background: Few studies have examined the frequency and survival implications of clinicopathologic stage discrepancy in oral cavity squamous cell carcinoma (SCC). Methods: Oral cavity SCC cases with full pathologic staging information were identified in the National Cancer Database (NCDB). Clinical and pathologic stages were compared. Multivariate logistic regressions were performed to identify factors associated with stage discrepancy. Results: There were 9110 cases identified, of which 67.3% of the cases were stage concordant, 19.9% were upstaged, and 12.8% were downstaged. The N classification discordance (28.5%) was more common than T classification discordance (27.6%). In cases of T classification discordance, downstaging is more common than upstaging (15.4% vs 12.1% of cases), but in cases of N classification discordance, the reverse is true; upstaging is much more common than downstaging (20.1 vs 8.4% of cases). Conclusion: Clinicopathologic stage discrepancy in oral cavity SCC is a common phenomenon that is associated with a number of clinical factors and has survival implications.
- Subjects
ORAL cancer diagnosis; TREATMENT of oral cancer; COMPUTED tomography; SQUAMOUS cell carcinoma; DIAGNOSIS; PATIENTS
- Publication
Head & Neck, 2018, Vol 40, Issue 4, p828
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25065