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- Title
Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck.
- Authors
Gore, Sinclair M.; Shaw, Douglas; Martin, Richard C. W.; Kelder, Wendy; Roth, Kathryn; Uren, Roger; Gao, Kan; Davies, Sarah; Ashford, Bruce G.; Ngo, Quan; Shannon, Kerwin; Clark, Jonathan R.
- Abstract
Background Nodal metastasis from cutaneous squamous cell carcinoma (SCC) is poorly predicted clinically and is associated with a high mortality rate. Methods From 2010 to 2013, patients with high-risk cutaneous SCC were assessed with sentinel node biopsy (SNB) either at the time of primary cutaneous tumor resection or at secondary wide local excision. Results Of 57 patients, 8 (14%) had nodal metastasis. Significant predictors of metastasis are the number of high-risk factors ( p = .008), perineural invasion (PNI; p = .05), and lymphovascular invasion (LVI; p = .05). During a mean of 19.4 months, 9 patients developed recurrence and 6 died of cutaneous SCC, indicating that over 1300 patients would be required for a randomized controlled trial with 80% power to detect a significant difference in disease-free survival. Conclusion Lymph node metastasis occurs in 14% of patients with high-risk cutaneous SCC. Larger studies will be required to identify which 'high-risk' factors should be considered as an indication for surgical assessment of the nodal basin. © 2015 Wiley Periodicals, Inc. Head Neck 38: E884-E889, 2016
- Subjects
HEAD &; neck cancer diagnosis; SQUAMOUS cell carcinoma; SKIN cancer; METASTASIS; SENTINEL lymph nodes; BIOPSY
- Publication
Head & Neck, 2016, Vol 38, pE884
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24120