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- Title
Laryngeal tumor volume as a predictor for thyroid cartilage penetration.
- Authors
Kats, Svetlana S.; Muller, Susan; Aiken, Ashley; Hudgins, Patricia A.; Wadsworth, J. Trad; Shin, Dong M.; Khuri, Fadlo; Beitler, Jonathan J.
- Abstract
Background Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT-based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage penetration among patients undergoing laryngectomy for squamous cell carcinoma (SCC) of the larynx. Methods Ninety-four patients were identified who underwent total laryngectomy for SCC of the larynx. GTV, as defined by preoperative diagnostic CT scan, was contoured and analyzed using treatment-planning software. Results Among the 49 nonirradiated patients, the mean GTVs of patients with ( n = 15) and without ( n = 34) thyroid cartilage penetration was 60.1 and 28.0 cm3 ( p = .004). When the nonirradiated patients were divided into 3 GTV groups (≤25 cm3, 25-50 cm3, >50 cm3), the rates of thyroid cartilage penetration were 23%, 17%, and 78%, respectively ( p = .003). Conclusions Laryngeal tumor volume is associated with pathologic evidence of thyroid cartilage penetration in nonirradiated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
- Subjects
LARYNGEAL cancer; TRACHEAL cartilage; LARYNGECTOMY; SQUAMOUS cell carcinoma; PREOPERATIVE period; CANCER tomography
- Publication
Head & Neck, 2013, Vol 35, Issue 3, p426
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.22995