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- Title
Weekly 5-fluorouracil plus cisplatin for concurrent chemoradiotherapy in patients with locally advanced head and neck cancer.
- Authors
Young Joo Lee; Chang Geol Lee; Byoung Chul Cho; Gwi Eon Kim; Hye Jin Choi; Eun Chang Choi; Joo Hyuk Sohn; Joo-Hang Kim
- Abstract
Background. In locally advanced head and neck cancer, concurrent chemoradiotherapy (CRT) with combined 5-fluorouracil (5-FU) and cisplatin has increased acute toxicities as well as survival. Once-weekly chemotherapeutic administration schedule may reduce severe toxicities. Thus, we investigated CRT using weekly administration of 5-FU–cisplatin in locally advanced head and neck cancer. Methods. In a single-arm, phase II study, CRT included radiation (70.0 Gy/35 fr) and weekly 5-FU (750 mg/m2) and cisplatin (20 mg/m2). Results. Thirty-two patients completed planned radiation. Thirteen (41%) achieved complete response, and 16 (50%) partial response. Twelve patients (38%) experienced acute grade 3 toxicities. Grade 3 mucositis, which was the most common toxicity, developed in 5 (16%) patients. The survival rates at 1 and 2 years were 81% and 76%, respectively. The progression-free survival rates at 1 and 2 years were 69% and 66%, respectively. Conclusions. We demonstrated weekly 5-FU-cisplatin with conventional radiotherapy was efficacious and feasible with high compliance rate in locally advanced head and neck cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
- Subjects
CANCER patients; ANTINEOPLASTIC agents; CISPLATIN; DRUG therapy; ELECTROTHERAPEUTICS
- Publication
Head & Neck, 2010, Vol 32, Issue 2, p235
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21177