We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy.
- Authors
Chen, Allen M.; Garcia, Joaquin; Bucci, M. Kara; Chan, Albert S.; Kaplan, Michael J.; Singer, Mark I.; Phillips, Theodore L.
- Abstract
Background. The optimal treatment for patients with locally recurrent carcinomas of the salivary glands is unclear. Methods. Ninety-nine patients underwent salvage surgery for locally recurrent salivary gland carcinomas. Eighty-one (82%) had previously received radiation. Thirty-seven patients (37%) received intraoperative radiation therapy (IORT) to a median dose of 15 Gy (range, 12–18 Gy) at the time of salvage. Results. The 1-, 3-, and 5-year estimates of local control after salvage surgery were 88%, 75%, and 69%, respectively. A Cox proportional hazard model identified positive margins (0.01) and the omission of IORT (p = .001) as independent predictors of local failure. The 5-year overall survival was 34%. Distant metastasis was the most common site of subsequent failure, occurring in 42% of patients. Conclusions. IORT significantly improves disease control for patients with locally recurrent carcinomas of the salivary glands. The high rate of distant metastasis emphasizes the need for effective systemic therapies. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
- Subjects
SALIVARY gland cancer; SURGERY; INTRAOPERATIVE radiotherapy; METASTASIS; MEDICAL research
- Publication
Head & Neck, 2008, Vol 30, Issue 1, p2
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.20651