We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis, reactivity, and antimicrobial properties of boron-containing 4-ethyl-3-thiosemicarbazide derivatives.
- Authors
Scott, Ryan S.; Veinot, Alex J.; Stack, Darcie L.; Gormley, Patrick T.; Khuong, B. Ninh; Vogels, Christopher M.; Masuda, Jason D.; Baerlocher, Felix J.; MacCormack, Tyson J.; Westcott, Stephen A.
- Abstract
The addition of 4-ethyl-3-thiosemicarbazide to benzaldehyde and boronic acid containing derivatives afforded the corresponding thiosemicarbazones (1–3) or benzodiazaborines (4–6) depending on the position of the boronic acid within the ring. All compounds have been characterized fully including an X-ray diffraction study of the methoxy-containing benzodiazaborine 6. Attempts to coordinate thiosemicarbazones 2 and 3 to palladium(II) acetate were unsuccessful; however, addition of the non-boron-containing derivative 1 to palladium afforded complex 7 whose molecular structure was determined by an X-ray diffraction study. The initial bioactivities of compounds 1–7 were examined against two fungi, Aspergillus niger and Saccharomyces cerevisiae, and two bacteria, Bacillus cereus and Pseudomonas aeruginosa.
- Subjects
ANTI-infective agents; BORON; PALLADIUM; THIOSEMICARBAZONES; MOLECULAR structure; X-ray diffraction
- Publication
Canadian Journal of Chemistry, 2018, Vol 96, Issue 10, p906
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2018-0108