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- Title
Atrial natriuretic peptide increases urodilatin in the circulation.
- Authors
Vesely, David L.; Overton, Rose M.; Blankenship, Mary; McCormick, Michael T.; Schocken, Douglas D.; Vesely, D L; Overton, R M; Blankenship, M; McCormick, M T; Schocken, D D
- Abstract
<bold>Background: </bold>Urodilatin is a 32-amino-acid (AA) peptide formed in the kidney.<bold>Methods: </bold>High-performance gel permeation chromatography and high-pressure liquid chromatography evaluation of plasma followed by sensitive urodilatin and atrial natriuretic peptide (ANP) assays revealed that urodilatin does circulate distinctly from ANP.<bold>Results: </bold>Urodilatin circulates at very low levels (i.e 9-12 pg/ml). Infusion of ANP increased the circulating concentration of urodilatin 135-fold (p < 0.001), suggesting that some of the effects of ANP may be mediated by urodilatin while long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide did not affect urodilatin in healthy humans (n = 30). Only ANP decreased the renal clearance of urodilatin (60-75%, p < 0.01). Urodilatin was metabolized into peptides smaller than 5 AAs as well as excreted intact into urine.<bold>Conclusion: </bold>Urodilatin circulates and is increased by ANP in humans.
- Subjects
ATRIAL natriuretic peptides; CHROMATOGRAPHIC analysis; COMPARATIVE studies; HIGH performance liquid chromatography; RESEARCH methodology; MEDICAL cooperation; PEPTIDES; RADIOIMMUNOASSAY; RESEARCH; EVALUATION research
- Publication
American Journal of Nephrology, 1998, Vol 18, Issue 3, p204
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000013338