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- Title
A Bioinformatics Analysis of Memory Consolidation Reveals Involvement of the Transcription Factor c-Rel.
- Authors
Levenson, Jonathan M.; Choi, Sangdun; Lee, Sun-Young; Cao, Yun Anna; Ahn, Hyung Jin; Worley, Kim C.; Pizzi, Marina; Liou, Hsiou-Chi; Sweatt, J. David
- Abstract
Consolidation of long-term memory (LTM) is a complex process requiring synthesis of new mRNAs and proteins. Many studies have characterized the requirement for de novo mRNA and protein synthesis; however, few studies have comprehensively identified genes regulated during LTM consolidation. We show that consolidation of long-term contextual memory in the hippocampus triggers altered expression of numerous genes encompassing many aspects of neuronal function. Like contextual memory formation, this altered gene expression required NMDA receptor activation and was specific for situations in which the animal formed an association between a physical context and a sensory stimulus. Using a bioinformatics approach, we found that regulatory elements for several transcription factors are over-represented in the upstream region of genes regulated during consolidation of LTM. Using a knock-out mouse, we found that c-rel, one of the transcription factors identified in our bioinformatics study, is necessary for hippocampus-dependent long-term memory formation.
- Subjects
LONG-term memory; PROTEINS; MESSENGER RNA; GENETIC regulation; GENE expression; BIOINFORMATICS; MEMORY; TRANSCRIPTION factors; GENES
- Publication
Journal of Neuroscience, 2004, Vol 24, Issue 16, p3933
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.5646-03.2004