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- Title
Fibulin-5: a novel biomarker for evaluating severity and predicting prognosis in patients with acute intracerebral haemorrhage.
- Authors
Hu, L.; Dong, M. ‐ X.; Zhao, H.; Xu, G. ‐ H.; Qin, X. ‐ Y.
- Abstract
Background and purpose The aim was to investigate relationships between serum fibulin-5 concentration and the severity or prognosis in patients with acute intracerebral haemorrhage ( ICH). Methods Consecutive ICH patients and healthy controls were included and clinical data were collected. National Institute of Health Stroke Scale ( NIHSS) and Glasgow Coma Scale ( GCS) were assessed at admission time within 3 days after bleeding. Cerebral haemorrhage volume was calculated and serum fibulin-5 concentration was measured at the same time. Multivariate linear regression analyses were performed to determine risk factors for serum fibulin-5 concentration and Spearman correlation coefficients were obtained to explore the relationships between fibulin-5 concentration and NIHSS or GCS scores. Patients were followed up for 3 months and the modified Rankin Scale was evaluated for all survivors. Receiver operating characteristic ( ROC) curves were obtained to explore fibulin-5 concentration in predicting prognosis. Results Serum fibulin-5 concentration had increased in ICH patients compared with healthy controls (65.86 ± 26.39 μg/l vs. 40.66 ± 5.03 μg/l, P = 0.00) and was mainly influenced by haemorrhage volume ( β = 0.905, P = 0.000) and extension to ventricles ( β = 10.173, P = 0.097). Serum fibulin-5 concentration was positively correlated with NIHSS score ( r = 0.511, P = 0.000) but inversely correlated with GCS score ( r = −0.585, P = 0.000). Based on the ROC curves, the optimal cut-off point was 80.68 μg/l for death, and the sensitivity and specificity values of serum fibulin-5 were 77.8% and 93.2%, whilst the optimal cut-off point was 48.45 μg/l for poor prognosis and the sensitivity and specificity values were 86.4% and 54.1%, respectively. Conclusions Serum fibulin-5 concentration can be regarded as a biomarker for evaluating disease severity and predicting prognosis in ICH patients.
- Subjects
FIBULINS; BIOMARKERS; CEREBRAL hemorrhage; PROGNOSIS; RECEIVER operating characteristic curves
- Publication
European Journal of Neurology, 2016, Vol 23, Issue 7, p1195
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/ene.13013