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- Title
A meta-analysis of the association between Helicobacter pylori infection and risk of hepatic encephalopathy.
- Authors
Li, Junwei; Yu, Hongwei; Wang, Yuexia; Wang, Bin; Zhang, Rongguang; Chen, Shuaiyin; Duan, Guangcai
- Abstract
Background Although the association between Helicobacter pylori (H. pylori) infection and hepatic encephalopathy (HE) has been confirmed through some research, the results of these relevant studies still remain controversial. We conducted an updated meta-analysis based on published studies to address this issue. Methods A systematic search was conducted, reviewing all studies about the association between H. pylori infection and HE, through November 2021. The outcome measures were presented as odds ratios (ORs) with 95% confidence intervals (CIs). Results In total, 13 studies provided data from 2784 subjects. H. pylori infection increased the risk of HE by 32% (OR = 2.32, 95% CI: 1.78–3.04). The effect became greater after hepatic encephalopathy was divided into overt HE and minimal hepatic encephalopathy (MHE) (HE OR = 2.66, 95% CI: 2.01–3.51, MHE OR = 1.74, 95% CI: 1.10–2.76). After H. pylori eradication, the risk of HE was reduced by 64%. Conclusions H. pylori infection is significantly associated with HE, and the infection rate of H. pylori also increases with the severity of HE. Eradication of H. pylori has a protective effect on HE. Therefore, it is necessary to eradicate H. pylori in HE treatments.
- Subjects
ONLINE information services; HEPATIC encephalopathy; META-analysis; CONFIDENCE intervals; MEDICAL information storage &; retrieval systems; SYSTEMATIC reviews; RISK assessment; RESEARCH funding; DESCRIPTIVE statistics; CHI-squared test; ODDS ratio; MEDLINE; HELICOBACTER diseases; DISEASE risk factors; DISEASE complications
- Publication
Journal of Public Health, 2023, Vol 45, Issue 2, p321
- ISSN
1741-3842
- Publication type
Article
- DOI
10.1093/pubmed/fdac078