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- Title
Drug formulations that require less than 0.1 mL of stock solution to prepare doses for infants and children.
- Authors
Uppal, Navjeet; Yasseen, Baseer; Seto, Winnie; Parshuram, Christopher S.
- Abstract
Intravenous doses of medications require formulations that permit accurate preparation and administration. Current equipment does not permit accurate measurement of volumes less than 0.1 mL. In a study of four hypothetical standard pediatric patients, we found that 28 common medications required less than 0.1 mL of available formulation to prepare the dose. In a clinical study of actual use in a pediatric intensive care unit (ICU), 5245 (7.4%) of 71 218 intravenous doses required preparation from less than 0.1 mL of stock solution. For 28.5% of the 1531 ICU admissions, at least one dose was prepared from a volume of less than 0.1 mL. Our findings identify a substantial source of dosing error. Correction will require revision of preparation methods, regulatory requirements and manufacturing practices.
- Subjects
INTRAVENOUS therapy for children; PEDIATRIC therapy; CRITICAL care medicine; DOSE-response relationship in poisons; PEDIATRICS
- Publication
Canadian Medical Association Journal (CMAJ), 2011, Vol 183, Issue 4, pE246
- Publication type
Article
- DOI
10.1503/cmaj.100467