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- Title
Protection against SHIV-KB9 Infection by Combining rDNA and rFPV Vaccines Based on HIV Multiepitope and p24 Protein in Chinese Rhesus Macaques.
- Authors
Chang Li; Zhenwei Shen; Xiao Li; Jieying Bai; Lin Zeng; Mingyao Tian; Ying Jin Song; Ming Ye; Shouwen Du; Dayong Ren; Cunxia Liu; Na Zhu; Dandan Sun; Yi Li; Ningyi Jin
- Abstract
Developing an effective vaccine against HIV infection remains an urgent goal.We used a DNA prime/fowlpox virus boost regimen to immunize Chinese rhesus macaques. The animals were challenged intramuscularly with pathogenic molecularly cloned SHIVKB9. Immunogenicity and protective efficacy of vaccines were investigated by measuring IFN-γ levels, monitoring HIV-specific binding antibodies, examining viral load, and analyzing CD4/CD8 ratio. Results show that, upon challenge, the vaccine group can induce a strong immune response in the body, represented by increased expression of IFN-γ, slow and steady elevated antibody production, reduced peak value of acute viral load, and increase in the average CD4/CD8 ratio. The current research suggests that rapid reaction speed, appropriate response strength, and long-lasting immune response time may be key protection factors for AIDS vaccine. The present study contributes significantly to AIDS vaccine and preclinical research.
- Subjects
RHESUS monkeys; RECOMBINANT DNA; EPITOPES; IMMUNOGLOBULINS; IMMUNOGENETICS
- Publication
Clinical & Developmental Immunology, 2012, p1
- ISSN
1740-2522
- Publication type
Article
- DOI
10.1155/2012/958404