We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Assessment of MR blood-oxygen-level-dependent (BOLD) cerebrovascular reactivity under general anesthesia in children with moyamoya.
- Authors
Choi, Eun Jung; Levin, David; Robertson, Amanda; Kirkham, Fenella J.; Muthusami, Prakash; Krishnan, Pradeep; Shroff, Manohar; Moharir, Mahendranath; Dirks, Peter; MacGregor, Daune; Pulcine, Elizabeth; Bhathal, Ishvinder; Kassner, Andrea; Walker, Kirstin; Allan, Warwick; deVeber, Gabrielle; Logan, William J.; Dlamini, Nomazulu
- Abstract
Background: Moyamoya is a progressive, non-atherosclerotic cerebral arteriopathy that may present in childhood and currently has no cure. Early diagnosis is critical to prevent a lifelong risk of neurological morbidity. Blood-oxygen-level-dependent (BOLD) MRI cerebrovascular reactivity (CVR) imaging provides a non-invasive, in vivo measure of autoregulatory capacity and cerebrovascular reserve. However, non-compliant or younger children require general anesthesia to achieve BOLD-CVR imaging. Objective: To determine the same-day repeatability of BOLD-CVR imaging under general anesthesia in children with moyamoya. Materials and methods: Twenty-eight examination pairs were included (mean patient age = 7.3 ± 4.0 years). Positive and negatively reacting voxels were averaged over signals and counted over brain tissue and vascular territory. The intraclass correlation coefficient (ICC), Wilcoxon signed-rank test, and Bland–Altman plots were used to assess the variability between the scans. Results: There was excellent-to-good (≥ 0.59) within-day repeatability in 18 out of 28 paired studies (64.3%). Wilcoxon signed-rank tests demonstrated no significant difference in the grey and white matter CVR estimates, between repeat scans (all p-values > 0.05). Bland–Altman plots of differences in mean magnitude of positive and negative and fractional positive and negative CVR estimates illustrated a reasonable degree of agreement between repeat scans and no systematic bias. Conclusion: BOLD-CVR imaging provides repeatable assessment of cerebrovascular reserve in children with moyamoya imaged under general anesthesia.
- Subjects
OXYGEN in the blood; GENERAL anesthesia; WILCOXON signed-rank test; INTRACLASS correlation; BLAND-Altman plot; FUNCTIONAL magnetic resonance imaging
- Publication
Pediatric Radiology, 2024, Vol 54, Issue 8, p1325
- ISSN
0301-0449
- Publication type
Article
- DOI
10.1007/s00247-024-05930-8