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- Title
Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections.
- Authors
Gumenscheimer, Marina; Balkow, Sandra; Simon, Markus M.; Jirillo, Emilio; Galanos, Chris; Freudenberg, Marina A.
- Abstract
We investigated the effect of a primary non-lethal infection with lymphocytic choriomeningitis virus (LCMV) on the course and outcome of a secondary infection with the Gram-negative Salmonella enterica serovar Typhimurium or the Gram-positive Listeria monocytogenes in mice. We found that at each stage of the viral infection the susceptibility of mice to bacterial super-infections changes dramatically and depends also on whether the secondary infection is a Gram-positive or Gram-negative one. The study shows that the outcome of the secondary infection is determined by a delicate balance between the overproduction of and the hypersensitivity to inflammatory cytokines (TNF-α and IFN-γ), as well as by the changes in blood leukocytes occurring in mice in the course of viral infection.
- Subjects
LYMPHOCYTIC choriomeningitis virus; LYMPHOCYTIC choriomeningitis; ARENAVIRUS diseases; MENINGITIS; ARENAVIRUSES; BACTERIAL diseases
- Publication
Medical Microbiology & Immunology, 2007, Vol 196, Issue 2, p79
- ISSN
0300-8584
- Publication type
Article
- DOI
10.1007/s00430-006-0030-1