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- Title
[<sup>11</sup>C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy.
- Authors
Giovacchini, Giampiero; Picchio, Maria; Coradeschi, Elisa; Scattoni, Vincenzo; Bettinardi, Valentino; Cozzarini, Cesare; Freschi, Massimo; Fazio, Ferruccio; Messa, Cristina
- Abstract
The accuracy of positron emission tomography (PET)/CT with [11C]choline for the detection of prostate cancer is not well established. We assessed the dependence of [11C]choline maximum standardized uptake values (SUVmax) in the prostate gland on cell malignancy, prostate-specific antigen (PSA) levels, Gleason score, tumour stage and anti-androgenic hormonal therapy. In this prospective study, PET/CT with [11C]choline was performed in 19 prostate cancer patients who subsequently underwent prostatectomy with histologic sextant analysis (group A) and in six prostate cancer patients before and after anti-androgenic hormonal therapy (bicalutamide 150 mg/day; median treatment of 4 months; group B). In group A, based on a sextant analysis with a [11C]choline SUVmax cutoff of 2.5 (as derived from a receiver-operating characteristic analysis), PET/CT showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 72, 43, 64, 51 and 60%, respectively. In the patient-by-patient analysis, no significant correlation was detected between SUVmax and PSA levels, Gleason score or pathological stage. On the contrary, a significant ( P < 0.05) negative correlation was detected between SUVmax and anti-androgenic therapy both in univariate ( r 2 = 0.24) and multivariate ( r 2 = 0.48) analyses. Prostate [11C]choline uptake after bicalutamide therapy significantly ( P < 0.05) decreased compared to baseline (6.4 ± 4.6 and 11.8 ± 5.3, respectively; group B). PET/CT with [11C]choline is not suitable for the initial diagnosis and local staging of prostate cancer. PET/CT with [11C]choline could be used to monitor the response to anti-androgenic therapy.
- Subjects
POSITRON emission tomography; CHOLINE; PROSTATE cancer; PROSTATE-specific antigen; PROSTATECTOMY; ANDROGENS
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2008, Vol 35, Issue 6, p1065
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-008-0716-2