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- Title
Modified variational Bayes EM estimation of hidden Markov tree model of cell lineages.
- Authors
Olariu, Victor; Coca, Daniel; Billings, Stephen A.; Tonge, Peter; Gokhale, Paul; Andrews, Peter W.; Kadirkamanathan, Visakan
- Abstract
Motivation: Human pluripotent stem cell lines persist in culture as a heterogeneous population of SSEA3 positive and SSEA3 negative cells. Tracking individual stem cells in real time can elucidate the kinetics of cells switching between the SSEA3 positive and negative substates. However, identifying a cell's substate at all time points within a cell lineage tree is technically difficult.
- Subjects
STEM cells; PLURIPOTENTIAL theory (Mathematics); BAYESIAN analysis; SYSTEMS biology; MOLECULAR biology
- Publication
Bioinformatics, 2009, Vol 25, Issue 21, p2824
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btp456