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- Title
Upcoming challenges for multiple sequence alignment methods in the high-throughput era.
- Authors
Kemena, Carsten; Notredame, Cedric
- Abstract
This review focuses on recent trends in multiple sequence alignment tools. It describes the latest algorithmic improvements including the extension of consistency-based methods to the problem of template-based multiple sequence alignments. Some results are presented suggesting that template-based methods are significantly more accurate than simpler alternative methods. The validation of existing methods is also discussed at length with the detailed description of recent results and some suggestions for future validation strategies. The last part of the review addresses future challenges for multiple sequence alignment methods in the genomic era, most notably the need to cope with very large sequences, the need to integrate large amounts of experimental data, the need to accurately align non-coding and non-transcribed sequences and finally, the need to integrate many alternative methods and approaches.
- Subjects
AMINO acid sequence; ALGORITHMS; GENOMES; COMPUTATIONAL biology; BIOLOGICAL models; RESEARCH
- Publication
Bioinformatics, 2009, Vol 25, Issue 19, p2455
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btp452