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- Title
Prevalance of Celiac Disease in Subjects With Diverticular Disease of the Colon.
- Authors
Aydin, Mesut; Ozer, Serhat; Dirik, Yaren; Tuncel, Elif Tugba; Dulger, Ahmet Cumhur
- Abstract
Objective: Celiac disease is a small bowel malabsorption syndrome that is caused by hypersensitivity to wheat in subjects who have positive HLA haplotypes DQ2 and DQ8. Diverticular disease of the colon is saccular dilatations of colon, which is seen mostly in adults older than 40. In this study, we tried to see whether celiac disease is protective for diverticular disease of the colon. Material and Method: We identified 114 (57 female; the mean age 58±4.1 years) patients with DDC during the 7-month period from January to October 2018. Age-matched control group (100 subjects; 50 female; the mean age 59±3.4 years) was selected from subjects without diverticular disease of the colon. Results: Among subjects with diverticular disease of the colon, only one tested positive for celiac disease serologically (Tissue Transglutaminase - TTG IgA and G). In control subjects with dyspepsia, 2.8% of subjects tested positive for celiac antibodies. There was a robust difference between groups in terms of TTG Ig A seropositivity (p=0.032, respectively). Conclusion: The results show an inverse relationship between diverticular disease of the colon and celiac disease. These data support that the presence of celiac antibodies may have a preventive role in the development of colon diverticular disease. The mechanism of the presented finding is still unclear. More research is needed.
- Subjects
DISEASE prevalence; CELIAC disease; DIVERTICULOSIS; COLON (Anatomy); SEROLOGY
- Publication
Van Tip Dergisi, 2021, Vol 28, Issue 3, p400
- ISSN
1300-2694
- Publication type
Article
- DOI
10.5505/vtd.2021.53323