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- Title
Highly Sensitive HBsAg, Anti-HBc and Anti HBsAg Titres in Early Diagnosis of HBV Reactivation in Anti-HBc-Positive Onco-Haematological Patients.
- Authors
Cerva, Carlotta; Salpini, Romina; Alkhatib, Mohammad; Malagnino, Vincenzo; Piermatteo, Lorenzo; Battisti, Arianna; Bertoli, Ada; Gersch, Jeff; Holzmayer, Vera; Kuhns, Mary; Cloherty, Gavin; Ferrari, Ludovica; Laura, Campogiani; Teti, Elisabetta; Cantonetti, Maria; Arcese, William; Ceccherini-Silberstein, Francesca; Perno, Carlo-Federico; Andreoni, Massimo; Svicher, Valentina
- Abstract
The role of novel HBV markers in predicting Hepatitis B virus reactivation (HBV-R) in HBsAg-negative/anti-HBc-positive oncohaematological patients was examined. One hundred and seven HBsAg-negative/anti-HBc-positive oncohaematological patients, receiving anti-HBV prophylaxis for >18 months, were included. At baseline, all patients had undetectable HBV DNA, and 67.3% were anti-HBs positive. HBV-R occurred in 17 (15.9%) patients: 6 during and 11 after the prophylaxis period. At HBV-R, the median (IQR) HBV-DNA was 44 (27–40509) IU/mL, and the alanine aminotransferase upper limit of normal (ULN) was 44% (median (IQR): 81 (49–541) U/L). An anti-HBc > 3 cut-off index (COI) plus anti-HBs persistently/declining to <50 mIU/mL was predictive for HBV-R (OR (95% CI): 9.1 (2.7–30.2); 63% of patients with vs. 15% without this combination experienced HBV-R (p < 0.001)). The detection of highly sensitive (HS) HBsAg and/or HBV-DNA confirmed at >2 time points, also predicts HBV-R (OR (95% CI): 13.8 (3.6–52.6); 50% of positive vs. 7% of negative patients to these markers experienced HBV-R (p = 0.001)). HS-HBs and anti-HBc titration proved to be useful early markers of HBV-R. The use of these markers demonstrated that HBV-R frequently occurs in oncohaematological patients with signs of resolved HBV infection, raising issues of proper HBV-R monitoring.
- Subjects
HEPATITIS B virus; HEPATITIS B; EARLY diagnosis; TITERS; ALANINE aminotransferase
- Publication
Biomedicines, 2022, Vol 10, Issue 2, p443
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10020443