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- Title
Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.
- Authors
Halaas, Nathalie Bodd; Blennow, Kaj; Idland, Ane-Victoria; Wyller, Torgeir Bruun; Ræder, Johan; Frihagen, Frede; Staff, Anne Cathrine; Zetterberg, Henrik; Watne, Leiv Otto
- Abstract
Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Delirium was diagnosed with the Confusion Assessment Method. Results: Median serum NFL (pg/mL) was elevated in delirium in hip fracture patients (94 vs. 54 pre- and 135 vs. 92 postoperatively, both p < 0.001). Median CSF NFL tended to be higher in hip fracture patients with delirium (1,804 vs. 1,636, p = 0.074). Serum and CSF NFL were positively correlated (ρ = 0.56, p < 0.001). Conclusion: Our findings support an association between neuroaxonal injury and delirium. The correlation between serum and CSF NFL supports the use of NFL as a blood biomarker in future delirium studies.
- Subjects
DIAGNOSIS of delirium; NEURONS; COGNITION in old age; CYTOSKELETAL proteins; BONE fractures; HIP joint injuries; POSTOPERATIVE period; ELECTIVE surgery; PREOPERATIVE period; OLD age; WOUNDS &; injuries
- Publication
Dementia & Geriatric Cognitive Disorders, 2018, Vol 46, Issue 5/6, p346
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000494754