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- Title
Proton Magnetic Resonance Spectroscopy and Magnetoencephalographic Estimation of Delta Dipole Density: A Combination of Techniques That May Contribute to the Diagnosis of Alzheimer’s Disease.
- Authors
Fernández, Alberto; García-Segura, Juan Manuel; Ortiz, Tomás; Montoya, Julia; Maestú, Fernando; Gil-Gregorio, Pedro; Campo, Pablo; Viaño, Juan
- Abstract
Whole-head magnetoencephalographic recordings were obtained from 10 patients with Alzheimer’s disease (AD) and 10 healthy controls in a resting position. Spectroscopic examinations were performed by means of a 1.5-tesla whole-body scanner in the temporoparietal regions of both hemispheres. The relationship between 1H-MRS-based and magnetoencephalography (MEG)-based measures and their conjoined capability to improve the diagnosis of AD were investigated in this study. Logistic regression analyses were performed. Three separated logistic models were calculated for 1H-MRS-based metabolites, low-frequency magnetic activity, and the combination of both measures. A combined myoinositol/N-acetyl aspartate (mI/NAA)-delta dipole density (DD) model predicted the diagnosis with 90% sensitivity and 100% specificity. Additionally, the combination of temporoparietal mI/NAA and delta DD values explained the variability of individuals’ cognitive status. The results support the notion that a multidisciplinary approach may improve the understanding and diagnosis of AD. Copyright © 2005 S. Karger AG, Basel
- Subjects
MAGNETOENCEPHALOGRAPHY; ALZHEIMER'S patients; SPECTRUM analysis; DIAGNOSIS; LOGISTIC regression analysis; METABOLITES
- Publication
Dementia & Geriatric Cognitive Disorders, 2005, Vol 20, Issue 2/3, p169
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000087094