We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Alpha-1-Antichymotrypsin Is Not Associated with the Increased Frequency of Apolipoprotein-E- Epsilon-4 Allele in Elderly Non-Demented Leprosy Patients.
- Authors
Endoh, Masumi; Ueki, Akira; Takahashi, Keikichi; Yamanaka, Hideki; Izumi, Shinzo; Tabira, Takeshi
- Abstract
In our previous study, elderly leprosy patients showed a low prevalence of senile dementia of the Alzheimer type, but the frequency of apolipoprotein E (APO-E) σ4 was elevated in non-demented elderly leprosy patients. Recent study has shown that Alzheimer's disease risk associated with APO-E σ4 is significantly increased by the α1-antichymotrypsin (ACT) genotype AA. Therefore we examined an association between ACT polymorphism and the APO-E σ4 allele in 350 leprosy patients. None of our data showed an association of ACT genotype and APO-E σ4 allele in leprosy patients. The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. Our present data suggest that ACT polymorphism is not associated with the increased frequency of APO-E σ4 in leprosy patients.
- Publication
Dementia & Geriatric Cognitive Disorders, 1998, Vol 9, Issue 1, p26
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000017018