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- Title
Effect of diabetes on the cutaneous microcirculation of the feet in patients with intermittent claudication.
- Authors
Klonizakis, M.; Manninga, G.; Lingam, K.; Donnelly, R.; Yeung, J. M. C.
- Abstract
AIMS: To evaluate endothelial-dependent and -independent cutaneous vasodilator responses in the feet of patients with peripheral arterial disease (PAD) with or without Type 2 diabetes. METHODS: Cutaneous microvascular responses in the dorsum of both lower limbs were measured in the supine position using Laser Doppler Fluximetry combined with iontophoretic administration of endothelial-dependent (acetylcholine, Ach) and -independent (sodium nitroprusside, SNP) vasodilators in diabetic (n = 19) and non diabetic (n = 17) patients with PAD (presenting as unilateral calf intermittent claudication (IC). RESULTS: In patients with diabetes and IC, endothelial-dependent vasodilation was significantly impaired in the symptomatic limb [74 (57,105) vs 68 (24,81) PU, Z =-2.79, p = 0.005] compared to the asymptomatic limb. Patients without diabetes showed no impairment of vasodilation. Resting ankle-brachial pressure index did not identify the presence of abnormalities in microvascular function. CONCLUSIONS: The combination of diabetes and PAD is associated with a reduction in endothelial-dependent cutaneous vasodilation in the feet without an associated reduction in endothelial independent vasodilation.
- Subjects
DIABETES; MICROCIRCULATION; INTERMITTENT claudication; ARTERIAL diseases; VASODILATION; ENDOTHELIUM diseases; PATIENTS
- Publication
Clinical Hemorheology & Microcirculation, 2015, Vol 61, Issue 3, p439
- ISSN
1386-0291
- Publication type
Article
- DOI
10.3233/CH-141907