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- Title
Combination of alfacalcidol and calcium improved handgrip strength and mobility among Indonesian older women: A randomized controlled trial.
- Authors
Setiati, Siti; Anugrahini; Fransiska, Jane E.; Istanti, Rahmi; Tamin, Tirza Z.
- Abstract
Aim: To determine the effect of alfacalcidol on muscle strength and functional mobility in Indonesian older women whose handgrip strength was low. Methods: A randomized, double‐blind controlled trial was carried out among 95 older women whose handgrip strength was ≤22 kg. Participants were randomized into two groups: 47 participants received alfacalcidol 0.5 μg/day and 48 participants received a placebo. Each participant in both groups was given calcium 500 mg/day. Handgrip strength as well as the Timed‐Up and Go test were measured before and after 90 days of intervention. Per protocol analysis after intervention between two groups was carried out. Results: There was a significant improvement of handgrip strength in the group that received alfacalcidol compared with the placebo group (15.50 <italic>vs</italic> 13.75; <italic>P</italic> = 0.003). The median time for the Timed‐Up and Go test in the alfacalcidol group also improved significantly compared with the placebo group (9.01 <italic>vs</italic> 10.07, <italic>P</italic> = 0.028). Conclusions: Alfacalcidol with daily doses of 0.5 μg significantly improved muscle strength and functional mobility in Indonesian older women. <bold>Geriatr Gerontol Int 2018; 18: 434–440</bold>.
- Subjects
INDONESIA; CALCIUM; COMBINATION drug therapy; GRIP strength; VITAMIN D; BODY movement; RANDOMIZED controlled trials
- Publication
Geriatrics & Gerontology International, 2018, Vol 18, Issue 3, p434
- ISSN
1444-1586
- Publication type
Article
- DOI
10.1111/ggi.13201