We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Early ‘‘Relapse’’ After Herpetic Encephalitis: Extensive White Matter Lesions in an Infant With Interferon Production Deficit.
- Authors
Maia, Raquel; Gouveia, Catarina; Moreira, Ana; Casanova, Jean Laurent; Sancho-Shimizu, Vanessa; Brito, Maria João
- Abstract
Acute secondary neurological deterioration after herpes simplex encephalitis has been reported. An immune-mediated process is thought to be responsible for some cases. The authors report the case of an infant who presented with fever, irritability, and orofacial involuntary movements, 15 days after herpes encephalitis onset. Polymerase chain reaction for herpes simplex virus was negative, and the magnetic resonance imaging revealed extensive white matter lesions. Chorea appeared only 11 days later. Raised immunoglobulin G index with oligoclonal bands and spreading of white matter lesions corroborated an immune-mediated etiology. An interferon production deficit was also detected. This case alerts that this form of ‘‘relapse’’ appears earlier than previously reported. A high level of suspicion is needed in the presence of atypical neurological deterioration and early white matter lesions should be considered as a warning sign. This case is also relevant because it associates, for the first time, an immune-mediated ‘‘relapse’’ to an interferon production deficit.
- Subjects
DISEASE relapse; INTERFERONS; ENCEPHALITIS; HERPES simplex virus; POLYMERASE chain reaction; ETIOLOGY of diseases
- Publication
Journal of Child Neurology, 2011, Vol 26, Issue 3, p369
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073810382140