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- Title
Re: "Risk Stratification Using a Novel Genetic Classifier Including PLEKHS1 Promoter Mutations for Differentiated Thyroid Cancer with Distant Metastasis" by Jung et al.
- Authors
Landa, Iñigo
- Abstract
B Dear Editor: b We read with interest the article by Jung I et al. i ([1]), assessing the role of I PLEKHS1 i promoter mutations as genetic markers of aggressive differentiated thyroid cancers (DTCs). We surveyed our set of 30 thyroid cancer cell lines to assess whether I PLEKHS1 i mutations are subjected to positive selection, as previously shown for key thyroid cancer lesions (e.g., I BRAF i , I TERT i , I TP53 i ) ([5]) and correlated the presence of I PLEKHS1 i alterations with our existing expression data.
- Subjects
THYROID cancer; GENETIC mutation; ANAPLASTIC thyroid cancer; METASTASIS; PALINDROMIC DNA
- Publication
Thyroid, 2021, Vol 31, Issue 4, p703
- ISSN
1050-7256
- Publication type
Article
- DOI
10.1089/thy.2020.0728