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- Title
Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results.
- Authors
Slot, Rosalinde E. R.; Verfaillie, Sander C. J.; Overbeek, Jozefien M.; Timmers, Tessa; Wesselman, Linda M. P.; Teunissen, Charlotte E.; Dols, Annemiek; Bouwman, Femke H.; Prins, Niels D.; Barkhof, Frederik; Lammertsma, Adriaan A.; Van Berckel, Bart N. M.; Scheltens, Philip; Sikkes, Sietske A. M.; Van der Flier, Wiesje M.
- Abstract
Background: We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria. Methods: The SCIENCe is a prospective cohort study of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection and optional amyloid positron emission tomography scan, with annual follow-up. The primary outcome measure is clinical progression. Results: Cross-sectional evaluation of the first 151 participants (age 64 ± 8, 44% female, Mini-Mental State Examination 29 ± 2) showed that 28 (25%) had preclinical Alzheimer's disease (AD) (amyloid status available n = 114 (75%)), 58 (38%) had subthreshold psychiatry, and 65 (43%) had neither. More severe subjective complaints were associated with worse objective performance. The SCD-plus criteria age ≥ 60 (OR 7.7 (95% CI 1.7–38.9)) and apolipoprotein E (genotype) e4 (OR 4.8 (95% CI 1.6–15.0)) were associated with preclinical AD. Conclusions: The SCIENCe study confirms that SCD is a heterogeneous group, with preclinical AD and subthreshold psychiatric features. We found a number of SCD-plus criteria to be associated with preclinical AD. Further inclusion and follow-up will address important questions related to SCD.
- Subjects
COGNITION disorders; NEUROPSYCHOLOGICAL tests; CLINICAL neuropsychology; NEUROLOGIC examination; ALZHEIMER'S disease; PSYCHIATRY
- Publication
Alzheimer's Research & Therapy, 2018, Vol 10, Issue 1, pN.PAG
- ISSN
1758-9193
- Publication type
Article
- DOI
10.1186/s13195-018-0390-y