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- Title
Therapeutic Drug Monitoring of Tyrosine Kinase Inhibitors in the Treatment of Advanced Renal Cancer.
- Authors
Puisset, Florent; Mseddi, Mourad; Mourey, Loïc; Pouessel, Damien; Blanchet, Benoit; Chatelut, Etienne; Chevreau, Christine
- Abstract
Simple Summary: The rational, benefits and limits of therapeutic drug monitoring as a routine practice are discussed for the seven tyrosine kinase inhibitor compounds currently used to treat advanced renal cell carcinoma. Seven tyrosine kinase inhibitor compounds with anti-angiogenic properties remain key drugs to treat advanced renal cell carcinoma. There is a strong rationale to develop therapeutic drug monitoring for these drugs. General considerations of such monitoring of the several groups of anticancer drugs are given, with a focus on oral therapy. Pharmacokinetics and the factors of inter- and intraindividual variabilities of these tyrosine kinase inhibitors are described together with an exhaustive presentation of their pharmacokinetic/pharmacodynamic relationships. The latter was observed in studies where every patient was treated with the same dose, and the results of several prospective studies based on dose individualization support the practice of increasing individual dosage in case of low observed plasma drug concentrations. Finally, the benefits and limits of therapeutic drug monitoring as a routine practice are discussed.
- Subjects
DRUG efficacy; PROTEIN-tyrosine kinase inhibitors; TUMOR classification; KIDNEY tumors; DRUG monitoring; DRUG interactions; BIOLOGICAL assay; PHARMACODYNAMICS
- Publication
Cancers, 2023, Vol 15, Issue 1, p313
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers15010313