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- Title
A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and β-galactosidase.
- Authors
Di Pierro, Francesco; Bertuccioli, Alexander; Marini, Eleonora; Ivaldi, Leandro
- Abstract
Aim: Lactose and complex carbohydrates maldigestion, common food intolerances due to low gut content of α- and β-galactosidase, lead to abdominal symptoms including pain, diarrhea, bloating, flatulence, and cramping. Commonly, intolerant patients are advised by physicians to avoid the offending foods (dairy foods, cereals, beans, etc). This food-limiting option, however, has possible nutritional risks. We have therefore evaluated the impact of using pure, entericcoated α- plus β-galactosidase on gut symptoms in intolerant subjects instead of avoidance of the offending foods. Methods: Sixteen subjects intolerant to lactose and/or complex carbohydrates were enrolled and evaluated in terms of gut symptoms with 1) uncontrolled diet, 2) diet devoid of offending foods, and 3) uncontrolled diet along with pure, enteric-coated α- and β-galactosidase (DDM Galactosidase®). Results: Even with the uncontrolled diet, intolerant subjects treated with DDM Galactosidase® exhibited reduced gut symptoms (bloating, flatulence, diarrhea, and constipation) significantly better than the control treatment as well as having a diet devoid of offending foods. Conclusion: DDM Galactosidase® is a valid and safe optional treatment to counteract lactose and complex carbohydrate intolerance in subjects who prefer not to avoid, at least partially, offending foods.
- Subjects
LACTOSE intolerance; OLIGOSACCHARIDES; FOOD intolerance; COMPLEX carbohydrate diet; AUTOIMMUNE diseases; DIARRHEA; CONSTIPATION
- Publication
Clinical & Experimental Gastroenterology, 2015, Vol 8, p95
- ISSN
1178-7023
- Publication type
Article
- DOI
10.2147/CEG.S79449