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- Title
Recombinant human interferon- in the treatment of condylomata acuminata.
- Authors
Dinsmore, Wallace; Jordan, Joe; O'Mahony, Colm; Harris, John R. W.; McMillan, Alexander; Radcliffe, Keith W.; Engrand, Patrick; Jackson, Brian W.; Galazka, Andrew R.; Abdul-Ahad, Ayad K.; Illingworth, John M.
- Abstract
The number of clinic consultations for condylomata acuminata (genital warts) has increased substantially during the last 30 years. Most infections produce benign lesions but a few types may be associated with cervical and penile cancers. Interferons (IFN) have shown antiviral properties to these infections and IFN- in particular has demonstrated a specific cytopathic effect in humans. A total of 124 patients with condylomata acuminata, the majority of whom had failed previous therapy, were treated intralesionally with either recombinant human interferon-beta 1a (r-hIFN--1a) or placebo. Up to 6 lesions were treated in each patient, and injections were made 3 times per week for a total of 9 injections. The patients were then followed up for 3 months. Efficacy assessments at all time points (day 19, week 6 and month 3) showed a clear advantage for the r-hIFN--1a interferon-beta treatment. Patients receiving rhIFN--1a showed a greater proportion of treatment success in terms of the complete or partial reduction (at least 50%) of the total area of the treated lesions. The treatment was also well tolerated. Headache, flu-like symptoms and asthenia were more common in patients receiving r-hIFN--1a, but these adverse events were generally mild in severity and rarely led to patient withdrawal. It was concluded that r-hIFN--1a has good efficacy in condylomata acuminata, and therefore presents a useful therapeutic alternative in this hard-to-treat condition.
- Subjects
INTERFERONS; CANCER patients; ANTIVIRAL agents; GLYCOPROTEINS; INJECTIONS; SKIN infections
- Publication
International Journal of STD & AIDS, 1997, Vol 8, Issue 10, p622
- ISSN
0956-4624
- Publication type
Article
- DOI
10.1258/0956462971918887