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- Title
Specific Clinical and Immunological Changes Following Mesenchymal Stem Cell Transplantation in COVID-19-induced Acute Respiratory Distress Syndrome Patients: A Phase-I Clinical Trial.
- Authors
Farkhad, Najmeh Kaffash; sedaghat, Alireza; Reihani, Hamidreza; Moghadam, Amir Adhami; Moghadam, Ahmad Bagheri; Ghaebi, Nayereh Khadem; Khodadoust, Mohamad Ali; Nikpoor, Amin Reza; Tavakol-Afshari, Jalil
- Abstract
Acute respiratory distress syndrome (ARDS) is a systemic inflammation resulting from immune system overactivity. ARDS is also a fatal complication of COVID-19. Mesenchymal stem cells (MSCs) have immune modulatory properties. This study evaluated the safety and efficacy of three times transplantation of umbilical cord-derived MSCs (UC-MSCs) in terms of specific immunological and clinical changes in mild-to-moderate COVID-19-induced ARDS patients. In this single-center, open-label, phase 1 clinical trial, 20 patients diagnosed with COVID-19 and mild-to-moderate ARDS were included and were divided into two groups: a control group receiving standard care and an intervention group receiving UC-MSC in addition to standard care. Three consecutive intravenous transplants of UC-MSC (1×106 cells/kg body weight per each transplant) were performed in the intervention group on days 1, 3, and 5. The biological assay was investigated four times (days 0, 5, 10, and 17). UC-MSCs improved the patients' clinical and paraclinical parameters, including leukocytosis, lymphopenia, thrombocytopenia, and liver enzyme abnormalities, compared to the control group. They also decreased pro-inflammatory lymphocytes (TH1 and TH17) and increased antiinflammatory T lymphocytes. Cell therapy also reduced the mean fluorescence intensity (MFI) in overactivated CD8+ T cells. These findings show that three UC-MSC injections could regulate a hyperactivated immune system in COVID-19-induced ARDS patients by decreasing the inflammatory T lymphocyte subset and can improve the patient's hematological condition and liver function. However, more studies are needed in this area.
- Subjects
ADULT respiratory distress syndrome; MESENCHYMAL stem cells; STEM cell transplantation; IMMUNOSPECIFICITY; LYMPHOPENIA; COVID-19
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2022, Vol 21, Issue 6, p687
- ISSN
1735-1502
- Publication type
Article
- DOI
10.18502/ijaai.v21i6.11530