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- Title
Development of antimicrobial hydrogels for burn wound treatment.
- Authors
CHIRILĂ, LAURA; POPESCU, ALINA; IGNAT, MĂDĂLINA; AVADANEI, MANUELA; LITE, CRISTINA MIHAELA
- Abstract
To obtain biomaterials with the potential for use in the treatment of first-burn injuries, this study focused on the development of several polymeric systems based on collagen-polyvinyl alcohol-active principles. The hydrogels were prepared using polymeric matrices formers (collagen and polyvinyl alcohol), water, and glycerol in the presence of the nonionic surfactant polysorbate 80 (Tween 80®) under proper homogenization. For the development of multifunctional textile materials designed for topical application, ciprofloxacin, chlorhexidine, tea tree essential oil, and curcumin were used as active principles. The obtained hydrogels were then immobilized by the padding method on 100% plain weave cotton. The functionalized textile materials were characterized in terms of their physico-mechanical and comfort characteristics, hydrophilicity, and antibacterial activity. The mass of all the functionalized textile materials increased compared to that of the untreated fabric, due to the amount of polymeric systems remaining after the functionalization process. The water vapour permeability and air permeability of the functionalized materials were lower than those of the untreated samples. Antibacterial activity was observed for all analysed samples, with inhibition zones between 14 mm (CUC-11 code in the presence of S. aureus) and 27 mm (CUC-1 code in the presence of E. coli), obtained for the textile materials treated with the hydrogels containing ciprofloxacin, exhibiting the most pronounced antibacterial effect compared to analogous samples containing chlorhexidine. The obtained experimental data suggest that these hydrogels are appropriate candidates for application in burn wound management.
- Subjects
POLYSORBATE 80; TEA tree oil; HYDROGELS; TOPICAL drug administration; ESSENTIAL oils; ESCHERICHIA coli; NONIONIC surfactants; CURCUMIN
- Publication
Industria Textila, 2024, Vol 75, Issue 2, p194
- ISSN
1222-5347
- Publication type
Article
- DOI
10.35530/IT.075.02.2021113